SOUTH SUDAN: ‘Malaria is preventable with the right tools’
Malaria remains a leading cause of illness and death among children in South Sudan. The country faces malaria outbreaks every year, worsened by factors such as flooding, poverty and a fragile health system. Despite the predictable recurrence of malaria peaks, immunisation coverage remains inadequate, contributing to overcrowded health facilities and an unbroken cycle of severe cases.
In response to these recurrent malaria outbreaks, our teams in Twic have implemented malaria prevention mass drug administration (MDA) in 2023 and 2024, and are supporting the Ministry of Health (MoH) in malaria vaccination rounds in Mayen Abun. These preventive measures have contributed to a significant reduction in malaria cases and severity, especially among vulnerable children.

"When the MDA started, I took my five children and got the drugs to prevent malaria. None of them got sick. I really appreciate that because I can't imagine what my children would have been like if they hadn't received this, how they could have suffered from malaria”, says Adior Manut, a South Sudanese person from Turalei internally displaced people’s camp in Mayen Abun, Twic.
Between May 2023 and October 2024, MSF launched seven rounds of the MDA campaign in Mayen Abun during malaria peaks to provide prophylaxis to children aged three months to 15 years. The target was to strengthen immunity and reduce cases among young children. By the end of October 2024, the team reached a total of 18,700 children with these MDA preventive measures.
Another mother, Arual Manyok, reflects: “If we compare before and after MSF started bringing malaria drugs, there is a big difference. All the children who received the drugs have not had malaria again. It is only the children who did not receive them who are getting sick.”
In July 2024, the South Sudanese authorities introduced the R21 malaria vaccine for existing malaria patients in high-burden areas such as Twic County, with MSF supporting the Ministry of Health (MoH) to roll out the vaccine for children aged five to 24 months.

As a result of preventive measures put in place, malaria cases in Twic have decreased. In our integrated case management community sites, for example, MSF recorded a decrease in malaria positivity rate consultation, from 79% between May to October in 2022, before MDA took place, to 70% in the same period in 2024.
Dr Mohamed Bashir, our project medical reference in Twic during 2024, affirmed: "The decrease in malaria cases and severe admissions in 2024 clearly shows that malaria preventive measures like MDA prevention rounds or the malaria vaccine response by the MoH can effectively provide protection and interrupt the disease cycle in our target paediatric population."

The effective results of MSF's malaria prevention intervention were made possible by the active involvement of the community. MSF worked with health promotion teams, local volunteers and community leaders to raise awareness of malaria prevention and ensure that the most vulnerable children were protected.
Despite the clear benefits of proactive prevention interventions in Twic County, lack of preparedness remains a concern in several regions of the country. Recurrent malaria outbreaks continue to cause overcrowded health facilities and an increase in severe cases across South Sudan.
"Health organisations should invest in more robust prevention and emergency response. The success we've seen in Mayen Abun shows that malaria is largely preventable with the right tools," Dr Bashir said.


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Jane Rabothata
About Doctors Without Borders (MSF)
Doctors Without Borders (MSF) is a global network of principled medical and other professionals who specialise in medical humanitarian work, driven by our common humanity and guided by medical ethics. We strive to bring emergency medical care to people caught in conflicts, crises, and disasters in more than 70 countries worldwide.
In South Africa, the organisation is recognised as one of the pioneers of providing Antiretroviral Treatment (ART) in the public sector and started the first HIV programmes in South Africa in 1999. Until today, the focus of MSF’s interventions in the country has primarily been on developing new testing and treatment strategies for HIV/AIDS and TB in Eshowe (Kwa-Zulu Natal) and Khayelitsha (Western Cape).
In Tshwane, we run a migration project, and we offer medical and psychosocial care to migrants, refugees, and asylum seekers, who struggle to access public health services under South Africa’s increasingly restrictive.
Previously we offered free, high-quality, confidential medical care to survivors of SGBV in Rustenburg.
To learn more about our work in South Africa, please visit this page on our website (www.msf.org.za). To support MSF’s work:
- SMS “JOIN” to 42110 to donate R30 Once-off
- Visit https://www.msf.org.za/donate